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Article

Tissue Distribution of Human AKR1C3 and Rat Homolog in the Adult Genitourinary System

23 Jun 2008

Abstract excerpt

Human aldo-keto reductase (AKR) 1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase) catalyzes androgen, estrogen, and prostaglandin metabolism. AKR1C3 is therefore implicated in regulating ligand access to the androgen receptor, estrogen receptor, and peroxisome proliferator activating receptor gamma in hormone target tissues. Recent reports on close relationships between...

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PMID: 18574251
DOI: 10.1369/jhc.2008.951384

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