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Topoisomerase levels determine chemotherapy response <i>in vitro</i> and <i>in vivo</i>

23 Jun 2008

Abstract excerpt

Topoisomerase poisons are chemotherapeutic agents that are used extensively for treating human malignancies. These drugs can be highly effective, yet tumors are frequently refractory to treatment or become resistant upon tumor relapse. Using a pool-based RNAi screening approach and a well characterized mouse model of lymphoma, we explored the genetic basis for heterogeneous responses to topoisomerase poisons in...

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PMID: 18574145
DOI: 10.1073/pnas.0803513105

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