Article
An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2010
Thermenos Heidi W, Goldstein Jill M, Milanovic Snezana M, Whitfield-Gabrieli Susan, Makris Nikos, Laviolette Peter, Koch Jennifer K, Faraone Stephen V, Tsuang Ming T, Buka Stephen L, Seidman Larry J
Abstract excerpt
First-degree relatives of persons with bipolar disorders (BDs) carry elevated risk for the illness, and manifest deficits in attention and memory (possible "endophenotypes"). However, there is only one published functional magnetic resonance imaging (fMRI) study of candidate endophenotypes in BD. We used fMRI to examine brain function in BD and in first-degree relatives performing a 2-back working memory (WM)...
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