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Article

The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Sept 2006

Chavez Juan C, Baranova Oxana, Lin Janice, Pichiule Paola

Abstract excerpt

In the ischemic or hypoxic brain, astrocytes appear to be one of the main sources of erythropoietin (EPO). In this study, we investigated the differential contribution of hypoxia inducible factor (HIF) isoforms to the regulation of hypoxic EPO expression in cultured astrocytes. In addition, using an in vitro model of oxygen-glucose deprivation (OGD), we studied the role of HIF-1alpha and HIF-2alpha in the...

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Source

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Identifiers

PMID: 16971531
DOI: 10.1523/JNEUROSCI.2838-06.2006
PMCID: PMC6674587

Genes

EPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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