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H3K9 trimethylation dictates neuronal ferroptosis through repressing <i>Tfr1</i>

24 Mar 2023

Abstract excerpt

Spontaneous intracerebral hemorrhage (ICH) is a devastating disease with high morbidity and mortality worldwide. We have previously shown that ferroptosis contributes to neuronal loss in ICH mice. The overload of iron and dysfunction of glutathione peroxidase 4 (GPx4) promote neuronal ferroptosis post-ICH. However, how epigenetic regulatory mechanisms affect the ferroptotic neurons in ICH remains unclear. In the...

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PMID: 36960698
DOI: 10.1177/0271678x231165653

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