Article

Overcoming constraints on the detection of recessive selection in human genes from population frequency data

2021-05-07

Abstract excerpt

The identification of genes that evolve under recessive natural selection is a longstanding goal of population genetics research with important applications to disease gene discovery. We found that commonly used methods to evaluate selective constraint at the gene level are highly sensitive to genes under heterozygous selection but ubiquitously fail to detect recessively evolving genes. Additionally, more sophisti...

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Literature Corpus work: cb4d183e-78f5-59fd-9c77-ffada2cb25d9
DOI: 10.1101/2021.05.06.443024

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