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Concurrent methylation of promoters from tumor associated genes predicts outcome in acute myeloid leukemia

1 Jan 2008

Abstract excerpt

By assessment of the methylation status of 25 candidate tumor suppressor genes (TSGs) in 119 acute myeloid leukemia (AML) patients and 5 controls, we aimed to determine whether simultaneous methylation of multiple TSGs exerts prognostic impact. Methylation-specific multiplex ligation probe amplification (MS-MLPA) revealed methylation of at least one TSG in 59/119 patients, while no methylation was found in...

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Share to Acute Myeloid Leukemia Research
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PMID: 18569637
DOI: 10.1080/10428190802035990

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