Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antiapoptotic activities of bcl-2 correlate with vascular maturation and transcriptional modulation of human endothelial cells.

Endothelium : journal of endothelial cell research - 1 Jan 2000

Enis David R, Dunmore Benjamin, Johnson Nicola, Pober Jordan S, Print Cristin G

Abstract excerpt

Overexpression of a caspase-resistant form of Bcl-2 (D34A) in human umbilical vein endothelial cells (ECs) implanted into immunodeficient mice promotes the maturation of human EC-lined microvessels invested by vascular smooth muscle cells (VSMCs) of mouse origin. In contrast, EC implants not overexpressing Bcl-2 form only simple, uncoated EC tubes. Here the authors compare the phenotypes of vessels formed in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Vessels
Share to Mice, SCID

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organ Culture Techniques

Share to Proto-Oncogene Proteins c-bcl-2

Share to Retroviridae

Share to Transduction, Genetic

Share to Transplantation, Heterologous

Share to Umbilical Veins

Source

Identifiers

PMID: 18568946
DOI: 10.1080/10623320802092393

Genes

ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antiapoptotic activities of bcl-2 correlate with vascular maturation and transcriptional modulation of human endothelial cells.PMID 18568946Read ↗

Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2.Semantic proximity Read ↗

BCL6B-dependent Suppression of ETV2 Hampers Endothelial Cell DifferentiationSemantic proximity Read ↗

Bcl‐2 proteins in development, health, and disease of the hematopoietic systemSemantic proximity Read ↗

Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis.Semantic proximity Read ↗

Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cellsSemantic proximity Read ↗

Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis.Semantic proximity Read ↗

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expressionSemantic proximity Read ↗

xIAP induces cell-cycle arrest and activates nuclear factor-kappaB : new survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells.Semantic proximity Read ↗

BRCA2-deficiency Causes Global Transcriptomic Alterations in Endothelial CellsSemantic proximity Read ↗

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure.Semantic proximity Read ↗

Expression of molecular mediators of apoptosis and their role in the pathogenesis of lower-extremity varicose veinsSemantic proximity Read ↗

Bcl-2 and Bcl-XL are indispensable for the late phase of mast cell development from mouse embryonic stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.