Article
Joint effects of inflammation and androgen metabolism on prostate cancer severity.
International journal of cancer - 15 Sept 2008
Rebbeck Timothy R, Rennert Hanna, Walker Amy H, Panossian Saarene, Tran Teo, Walker Kyle, Spangler Elaine, Patacsil-Coomes Margerie, Sachdeva Rajeev, Wein Alan J, Malkowicz S Bruce, Zeigler-Johnson Charnita
Abstract excerpt
Multiple pathways of prostate carcinogenesis have been proposed, including those involving androgen metabolism and inflammation. These pathways are not independent, and may act together in prostate cancer etiology: androgens promote both inflammatory processes and serve as mitogens in prostate tumor growth. To explore the possible joint effects of these pathways in prostate cancer severity, we studied 1,090...
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