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Article

CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer.

Cancer research - 15 Nov 2004

Zeigler-Johnson Charnita, Friebel Tara, Walker Amy H, Wang Yiting, Spangler Elaine, Panossian Saarene, Patacsil Margerie, Aplenc Richard, Wein Alan J, Malkowicz S Bruce, Rebbeck Timothy R

Abstract excerpt

The CYP3A genes reside on chromosome 7q21 in a multigene cluster. The enzyme products of CYP3A4 and CYP3A43 are involved in testosterone metabolism. CYP3A4 and CYP3A5 have been associated previously with prostate cancer occurrence and severity. To comprehensively examine the effects of these gene...

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PMID: 15548719
DOI: 10.1158/0008-5472.CAN-04-1651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15548719-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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