Article
CCR2 and CCR5 genes polymorphisms in benign prostatic hyperplasia and prostate cancer.
Human immunology - 1 Aug 2013
Zambra Francis Maria Báo, Biolchi Vanderlei, Brum Ilma Simoni, Chies José Artur Bogo
Abstract excerpt
Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are two chronic conditions, very common in aged men, that have been associated to inflammatory process. Chemokines and their receptors are recognized as critical mediators of inflammatory responses, they regulate immune cell migration and are implicated in tumor pathogenesis. The impact of two chemokine receptor gene polymorphisms, CCR2-64I (rs1799864)...
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