Article

Distinct αβ double-negative T cells discriminate between autoimmune lymphoproliferative syndrome and RAS-associated lymphoproliferative disease

2023-06-05

Abstract excerpt

<title>Abstract</title> Autoimmune lymphoproliferative syndrome (ALPS) is a disease of lymphocyte homeostasis caused by FAS-mediated apoptotic pathway dysfunction and is characterized by non-malignant lymphoproliferation with an increased number of TCRαβ+CD4−CD8− double-negative T cells (αβDNTs). Conversely, RAS-associated leuko-proliferative disease (RALD), which is caused by...

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Literature Corpus work: 8d69375c-3b37-519d-936e-eeda32e330fc
DOI: 10.21203/rs.3.rs-2997287/v1

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