Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly restricted human T cell repertoire in peripheral blood and tissue-infiltrating lymphocytes in Omenn's syndrome.

15 Jul 1998

Abstract excerpt

Omenn's syndrome is an inherited human combined immunodeficiency condition characterized by the presence of a large population of activated and tissue-infiltrating T cells. Analysis of the TCRB repertoire revealed a highly restricted TCRBV usage in three patients. More strikingly, T cell clones from the three patients expressed TCRB chains with VDJ junction similarities, suggesting a common antigenic specificity....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to Immunodeficiency and Autoimmune Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9664072
DOI: 10.1172/jci332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly restricted human T cell repertoire in peripheral blood and tissue-infiltrating lymphocytes in Omenn's syndrome.PMID 9664072Read ↗

Restricted heterogeneity of T lymphocytes in combined immunodeficiency with hypereosinophilia (Omenn's syndrome).Semantic proximity Read ↗

Intrathymic restriction and peripheral expansion of the T-cell repertoire in Omenn syndrome.Semantic proximity Read ↗

Characterization of T and B cell repertoire diversity in patients with RAG deficiencySemantic proximity Read ↗

Human TCR alpha/beta+ CD4-CD8- double-negative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vbeta TCR diversity and are clonally related to CD8+ T cells.Semantic proximity Read ↗

Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development.Semantic proximity Read ↗

Omenn syndrome does not live by V(D)J recombination alone.Semantic proximity Read ↗

Reduced central tolerance in Omenn syndrome leads to immature self-reactive oligoclonal T cellsSemantic proximity Read ↗

A biased Vα24+ T-cell repertoire leads to circulating NKT-cell defects in a multiple sclerosis patient at the onset of his diseaseSemantic proximity Read ↗

Different TCRBV genes generate biased patterns of V-D-J diversity in human T cells.Semantic proximity Read ↗

Omenn's syndrome occurring in patients without mutations in recombination activating genes.Semantic proximity Read ↗

Clonal and constricted T cell repertoire in Common Variable Immune Deficiency.Semantic proximity Read ↗

Oligoclonal TRBV gene usage among CD8(+) T cells in monoclonal B lymphocytosis and CLL.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.