Article
Heterogeneous dysregulation of microRNAs across the autism spectrum.
Neurogenetics - 1 Jul 2008
Abu-Elneel Kawther, Liu Tsunglin, Gazzaniga Francesca S, Nishimura Yuhei, Wall Dennis P, Geschwind Daniel H, Lao Kaiqin, Kosik Kenneth S
Abstract excerpt
microRNAs (miRNAs) are approximately 21 nt transcripts capable of regulating the expression of many mRNAs and are abundant in the brain. miRNAs have a role in several complex diseases including cancer as well as some neurological diseases such as Tourette's syndrome and Fragile x syndrome. As a genetically complex disease, dysregulation of miRNA expression might be a feature of autism spectrum disorders (ASDs)....
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