Article
Dynamic localization of the Swe1 regulator Hsl7 during the Saccharomyces cerevisiae cell cycle.
Molecular biology of the cell - 1 Jun 2001
Cid V J, Shulewitz M J, McDonald K L, Thorner J
Abstract excerpt
In Saccharomyces cerevisiae, entry into mitosis requires activation of the cyclin-dependent kinase Cdc28 in its cyclin B (Clb)-associated form. Clb-bound Cdc28 is susceptible to inhibitory tyrosine phosphorylation by Swe1 protein kinase. Swe1 is itself negatively regulated by Hsl1, a Nim1-related protein kinase, and by Hsl7, a presumptive protein-arginine methyltransferase. In vivo all three proteins localize to...
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