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Article

ATP hydrolysis and pristinamycin IIA inhibition of the Staphylococcus aureus Vga(A), a dual ABC protein involved in streptogramin A resistance.

The Journal of biological chemistry - 12 Sept 2008

Jacquet Eric, Girard Jean-Marie, Ramaen Odile, Pamlard Olivier, Lévaique Hélène, Betton Jean-Michel, Dassa Elie, Chesneau Olivier

Abstract excerpt

In Gram-positive bacteria, a large subfamily of dual ATP-binding cassette proteins confers acquired or intrinsic resistance to macrolide, lincosamide, and streptogramin antibiotics by a far from well understood mechanism. Here, we report the first biochemical characterization of one such protein, Vga(A), which is involved in streptogramin A (SgA) resistance among staphylococci. Vga(A) is composed of two...

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Identifiers

PMID: 18562322
DOI: 10.1074/jbc.M800418200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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