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Article

ATPase activity of non-ribosomal peptide synthetases.

Biochimica et biophysica acta - 14 Jan 2004

Pavela-Vrancic Maja, Dieckmann Ralf, von Döhren Hans

Abstract excerpt

Adenylation domains of non-ribosomal peptide synthetases (NRPS) catalyse the formation of aminoacyl adenylates, and in addition synthesize mono- and dinucleoside polyphosphates. Here, we show that NRPS systems furthermore contain an ATPase activity in the range of up to 2 P(i)/min. The hydrolysis rate by apo-tyrocidine synthetase 1 (apo-TY1) is enhanced in the presence of non-cognate amino acid substrates,...

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Identifiers

PMID: 14726208
DOI: 10.1016/j.bbapap.2003.09.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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