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Article

Association of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Variants with Ischemic Stroke and Its Subtype.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Feb 2017

Huang Xiao-Ya, Han Li-Ya, Huang Xiang-Dong, Guan Chao-Hong, Mao Xin-Lei, Ye Zu-Sen

Abstract excerpt

BACKGROUND: Genetic variations in the genes of matrix metalloproteinases (MMPs) may play an important role in the pathogenesis of ischemic stroke (IS). Here we investigate the association between MMP-1 -1607 1G/2G and MMP-3 -1171 5A/6A genetic polymorphisms and etiological subtypes of IS in the Han Chinese population. METHODS: A total of 640 eligible patients with IS and 637 age- and gender-matched apparently...

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PMID: 27793533
DOI: 10.1016/j.jstrokecerebrovasdis.2016.09.034

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