Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a Posttranslational Mechanism for the Regulation of hERG1 K+ Channel Expression and hERG1 Current Density in Tumor Cells

17 Jun 2008

Abstract excerpt

A common feature of tumor cells is the aberrant expression of ion channels on their plasma membrane. The molecular mechanisms regulating ion channel expression in cancer cells are still poorly known. K(+) channels that belong to the human ether-a-go-go-related gene 1 (herg1) family are frequently misexpressed in cancer cells compared to their healthy counterparts. We describe here a posttranslational mechanism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac electrophysiology and arrhythmias
Share to Ion channel regulation and function
Share to Ion Transport and Channel Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18559421
DOI: 10.1128/mcb.00304-08

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a Posttranslational Mechanism for the Regulation of hERG1 K+ Channel Expression and hERG1 Current Density in Tumor CellsPMID 18559421Read ↗

HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential.Semantic proximity Read ↗

Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome.Semantic proximity Read ↗

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1.Semantic proximity Read ↗

Frequent aberrant expression of the human ether à go-go (hEAG1) potassium channel in head and neck cancer: pathobiological mechanisms and clinical implicationsSemantic proximity Read ↗

Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoforms.Semantic proximity Read ↗

Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatmentSemantic proximity Read ↗

The role of monoubiquitination in endocytic degradation of human ether-a-go-go-related gene (hERG) channels under low K+ conditions.Semantic proximity Read ↗

Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System.Semantic proximity Read ↗

Cell Cycle-dependent Expression of HERG1 and HERG1B Isoforms in Tumor CellsSemantic proximity Read ↗

Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?Semantic proximity Read ↗

Involvement of potassium channels in the progression of cancer to a more malignant phenotype.Semantic proximity Read ↗

K+ channels and cell cycle progression in tumor cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.