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Article

Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants.

BMC genomics - 16 Jun 2008

Huang Lingkang, Heinloth Alexandra N, Zeng Zhao-Bang, Paules Richard S, Bushel Pierre R

Abstract excerpt

BACKGROUND: Some of the biochemical events that lead to necrosis of the liver are well-known. However, the pathogenesis of necrosis of the liver from exposure to hepatotoxicants is a complex biological response to the injury. We hypothesize that gene expression profiles can serve as a signature to predict the level of necrosis elicited by acute exposure of rats to a variety of hepatotoxicants and postulate that...

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Identifiers

PMID: 18558008
DOI: 10.1186/1471-2164-9-288
PMCID: PMC2478688

Genes

JUN
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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