Article
COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse.
International urogynecology journal and pelvic floor dysfunction - 1 Nov 2008
Rodrigues Andrea Moura, Girão Manoel João Batista Castello, da Silva Ismael Dale Cotrim Guerreiro, Sartori Marair Gracio Ferreira, Martins Karina de Falco, Castro Rodrigo de Aquino
Abstract excerpt
The objective of this study was to verify the possible association between the Sp1-binding site polymorphism and genital prolapse. A case-control study was conducted in 107 patients with stages III and IV genital prolapse. The control group included 209 women with stages 0 and I. The polymorphism of type I collagen Sp1-binding site was identified by amplification of the first intron of the COL1A1 gene. We did not...
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