Article
Linear time probabilistic algorithms for the singular haplotype reconstruction problem from SNP fragments.
Journal of computational biology : a journal of computational molecular cell biology - 1 Jun 2008
Chen Zhixiang, Fu Bin, Schweller Robert, Yang Boting, Zhao Zhiyu, Zhu Binhai
Abstract excerpt
In this paper, we develop a probabilistic model to approach two realistic scenarios regarding the singular haplotype reconstruction problem--the incompleteness and inconsistency that occurred in the DNA sequencing process to generate the input haplotype fragments, and the common practice used to generate synthetic data in experimental algorithm studies. We design three algorithms in the model that can reconstruct...
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