Article
The incomplete perfect phylogeny haplotype problem.
Journal of bioinformatics and computational biology - 1 Apr 2005
Kimmel Gad, Shamir Ron
Abstract excerpt
The problem of resolving genotypes into haplotypes, under the perfect phylogeny model, has been under intensive study recently. All studies so far handled missing data entries in a heuristic manner. We prove that the perfect phylogeny haplotype problem is NP-complete when some of the data entries are missing, even when the phylogeny is rooted. We define a biologically motivated probabilistic model for genotype...
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