Article
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.
Nucleic acids research - 18 Mar 2016
Schneider Anna, Corona Angela, Spöring Imke, Jordan Mareike, Buchholz Bernd, Maccioni Elias, Di Santo Roberto, Bodem Jochen, Tramontano Enzo, Wöhrl Birgitta M
Abstract excerpt
We analyzed a multi-drug resistant (MR) HIV-1 reverse transcriptase (RT), subcloned from a patient-derived subtype CRF02_AG, harboring 45 amino acid exchanges, amongst them four thymidine analog mutations (TAMs) relevant for high-level AZT (azidothymidine) resistance by AZTMP excision (M41L, D67N, T215Y, K219E) as well as four substitutions of the AZTTP discrimination pathway (A62V, V75I, F116Y and Q151M). In...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.