Article
Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia.
The international journal of neuropsychopharmacology - 28 Dec 2014
Fedorenko Olga Yu, Loonen Anton J M, Lang Florian, Toshchakova Valentina A, Boyarko Evgenia G, Semke Arkadiy V, Bokhan Nikolay A, Govorin Nikolay V, Aftanas Lyubomir I, Ivanova Svetlana A
Abstract excerpt
BACKGROUND: Tardive dyskinesia is a disorder characterized by involuntary muscle movements that occur as a complication of long-term treatment with antipsychotic drugs. It has been suggested to be related to a malfunctioning of the indirect pathway of the motor part of the cortical-striatal-thalamic-cortical circuit, which may be caused by oxidative stress-induced neurotoxicity. METHODS: The purpose of our study...
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