Article
Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk.
Cancer research - 15 Jun 2008
McWilliams Robert R, Bamlet William R, Cunningham Julie M, Goode Ellen L, de Andrade Mariza, Boardman Lisa A, Petersen Gloria M
Abstract excerpt
Base excision repair and nucleotide excision repair are vital responses to multiple types of DNA damage, including damage from tobacco exposure. Single-nucleotide polymorphisms (SNP) in these pathways may affect DNA repair capacity and therefore influence risk for cancer development. We performed a clinic-based, case-control study comprising 481 consecutive patients with confirmed pancreatic adenocarcinoma and...
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