Article
The different efficacy of gefitinib or erlotinib according to epidermal growth factor receptor exon 19 and exon 21 mutations in Korean non-small cell lung cancer patients.
Journal of cancer research and clinical oncology - 1 Apr 2011
Sun Jong-Mu, Won Young-Woong, Kim Seung Tae, Kim Jung Hoon, Choi Yoon-La, Lee Jeeyun, Park Yeon Hee, Ahn Jin Seok, Park Keunchil, Ahn Myung-Ju
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) mutations are associated with sensitivity to gefitinib or erlotinib in non-small cell lung cancer (NSCLC). We investigated the relationships between the two most common types of somatic EGFR mutations, exon 19 deletions and L858R mutations, and clinical outcomes of Korean NSCLC patients after treatment with gefitinib or erlotinib. PATIENTS AND METHODS: In Korean...
Topics
- Adult
- Aged
- Carcinoma, Non-Small-Cell Lung
- Disease-Free Survival
- ErbB Receptors
- Erlotinib Hydrochloride
- Exons
- Female
- Gefitinib
- Genotype
- Humans
- Lung Neoplasms
- Male