Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer

9 Jun 2008

Abstract excerpt

The imprinted insulin-like growth factor 2 (IGF2) gene is expressed predominantly from the paternal allele. Loss of imprinting (LOI) associated with hypomethylation at the promoter proximal sequence (DMR0) of the IGF2 gene was proposed as a predisposing constitutive risk biomarker for colorectal cancer. We used pyrosequencing to assess whether IGF2 DMR0 methylation is either present constitutively prior to cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18541649
DOI: 10.1093/hmg/ddn163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatically acquired hypomethylation of IGF2 in breast and colorectal cancerPMID 18541649Read ↗

Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 gene.Semantic proximity Read ↗

Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpressionSemantic proximity Read ↗

Hypomethylation of the IGF2 DMR in Colorectal Tumors, Detected by Bisulfite Pyrosequencing, Is Associated With Poor PrognosisSemantic proximity Read ↗

Distinct Methylation Changes at the IGF2-H19 Locus in Congenital Growth Disorders and CancerSemantic proximity Read ↗

Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications.Semantic proximity Read ↗

Loss of IGF2 imprinting: a potential marker of colorectal cancer risk.Semantic proximity Read ↗

Examination of IGF2 and H19 loss of imprinting in bladder cancer.Semantic proximity Read ↗

Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer.Semantic proximity Read ↗

Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients.Semantic proximity Read ↗

Familial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions.Semantic proximity Read ↗

Aberrant methylation of imprinted genes is associated with negative hormone receptor status in invasive breast cancer.Semantic proximity Read ↗

IGF2 DMR0 Methylation, Loss of Imprinting, and Patient Prognosis in Esophageal Squamous Cell CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.