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Article

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

Cancer cell - 1 Jun 2008

Wei Junping, Wunderlich Mark, Fox Catherine, Alvarez Sara, Cigudosa Juan C, Wilhelm Jamie S, Zheng Yi, Cancelas Jose A, Gu Yi, Jansen Michael, Dimartino Jorge F, Mulloy James C

Abstract excerpt

Faithful modeling of mixed-lineage leukemia in murine cells has been difficult to achieve. We show that expression of MLL-AF9 in human CD34+ cells induces acute myeloid, lymphoid, or mixed-lineage leukemia in immunodeficient mice. Some leukemia stem cells (LSC) were multipotent and could be lineage directed by altering either the growth factors or the recipient strain of mouse, highlighting the importance of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18538732
DOI: 10.1016/j.ccr.2008.04.020
PMCID: PMC2486365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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