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Article

Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol.

Pharmacology, biochemistry, and behavior - 1 Dec 2012

Ashenhurst James R, Bujarski Spencer, Ray Lara A

Abstract excerpt

Naltrexone, one of four FDA-approved pharmacotherapies for alcohol dependence, has shown moderate efficacy in clinical trials. Pharmacogenetic effects have been reported such that allelic variation at the gene encoding the mu-opioid receptor (OPRM1, rs1799971) predicts naltrexone-induced blunting of the positively reinforcing effects of alcohol. However, naltrexone also binds, albeit to a lesser degree, to kappa...

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Source

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Identifiers

PMID: 22954510
DOI: 10.1016/j.pbb.2012.08.019
PMCID: PMC3683577

Genes

OPRD1
OPRK1
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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