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Article

A critical role for Gly25 in the B chain of human thrombin.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2005

Akhavan S, Miteva M A, Villoutreix B O, Venisse L, Peyvandi F, Mannucci P M, Guillin M C, Bezeaud A

Abstract excerpt

We have recently identified (Akhavan S et al., Thromb Haemost 2000; 84: 989-97) a patient with a mild bleeding diathesis associated to an homozygous mutation in the thrombin B chain (Gly25Ser, chymotrypsinogen numbering, i.e. position 330 in human prothrombin numbering). Transient transfection of wild-type prothrombin (FII-WT) and mutant prothrombin (designated FII-G25(330)S) cDNA in COS-7 cells showed a mild...

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PMID: 15634277
DOI: 10.1111/j.1538-7836.2004.01086.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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