Article
Child hospitalization due to severe malaria is associated with the ICAM-1Kilifi allele but not adherence patterns of Plasmodium falciparum infected red blood cells to ICAM-1.
Acta tropica - 1 Oct 2010
Mwanziva Charles, Mpina Maximillian, Balthazary Sakurani, Mkali Humphrey, Mbugi Erasto, Mosha Franklin, Chilongola Jaffu
Abstract excerpt
This study aimed at determining whether the predisposition of a mutation at position 179 of the ICAM-1 gene to child hospitalization due to malaria was mediated by changes in adherence properties of IRBCs to ICAM-1. ICAM-1 genotypes were determined by nested polymerase chain reaction of isolated DNA from filter blood spots followed by Restriction Fragment Length Polymorphism (RFLP). Plasmodium falciparum...
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