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Article

Association between genetic and environmental factors and the risk of Alzheimer's disease.

Folia neuropathologica - 1 Jan 2008

Styczyńska Maria, Strosznajder Joanna B, Religa Dorota, Chodakowska-Zebrowska Małgorzata, Pfeffer Anna, Gabryelewicz Tomasz, Czapski Grzegorz A, Kobryś Małgorzata, Karciauskas Gytis, Barcikowska Maria

Abstract excerpt

The only well confirmed genetic risk factor for sporadic Alzheimer's disease (AD) is the possession of apolipoprotein E (APOE) epsilon4 allele. As it contributes to 40-70% of AD cases, a large proportion of genetic variance may be determined by additional loci. Our aim was to estimate how reported genetic factors (APOE, NOS3, MTHFR) interact to increase the risk for AD and combine them with environmental factors...

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Source

Identifiers

PMID: 19169966

Genes

APOE
NOS3
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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