Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4+ T lymphocytes in trans.

Journal of virology - 1 Aug 2008

van Montfort Thijs, Thomas Adri A M, Pollakis Georgios, Paxton William A

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) preferentially utilizes the CCR5 coreceptor for target cell entry in the acute phase of infection, while later in disease progression the virus switches to the CXCR4 coreceptor in approximately 50% of patients. In response to HIV-1 the adaptive immune response is triggered, and antibody (Ab) production is elicited to block HIV-1 entry. We recently determined that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules
Share to Dendritic Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

Share to HIV Envelope Protein gp41

Share to Immune System

Share to Lectins, C-Type

Share to Receptors, CCR5

Share to Receptors, CXCR4

Source

Open in PubMed Open full text

Identifiers

PMID: 18524826
DOI: 10.1128/JVI.00245-08
PMCID: PMC2519566

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4+ T lymphocytes in trans.PMID 18524826Read ↗

Differential transmission of human immunodeficiency virus type 1 by distinct subsets of effector dendritic cells.Semantic proximity Read ↗

Selective transmission of some HIV-1 subtype C variants might depend on Envelope stimulating dendritic cells to secrete IL-10.Semantic proximity Read ↗

HIV-1 Reprograms CD4 T Cell Responses by Impairing Antigen-specific Communication with Dendritic CellsSemantic proximity Read ↗

Phenotypic properties of transmitted founder HIV-1.Semantic proximity Read ↗

HIV-1 replicates and persists in vaginal epithelial dendritic cellsSemantic proximity Read ↗

Elevated HIV Infection of CD4 T Cells in MRKAd5 Vaccine Recipients Due to CD8 T Cells Targeting Adapted Epitopes.Semantic proximity Read ↗

IFN-α induces APOBEC3G, F, and A in immature dendritic cells and limits HIV-1 spread to CD4+ T cells.Semantic proximity Read ↗

Infection of Human Dendritic Cells by a Sindbis Virus Replicon Vector Is Determined by a Single Amino Acid Substitution in the E2 GlycoproteinSemantic proximity Read ↗

The HIV-2 genotype and the HIV-1 syncytium-inducing phenotype are associated with a lower virus replication in dendritic cells.Semantic proximity Read ↗

Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-1 variants emerging during AIDS progression.Semantic proximity Read ↗

Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

Studies on cross presentation of antigen by human dendritic cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.