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Article

Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-1 variants emerging during AIDS progression.

Retrovirology - 27 Mar 2008

Borggren Marie, Repits Johanna, Kuylenstierna Carlotta, Sterjovski Jasminka, Churchill Melissa J, Purcell Damian F J, Karlsson Anders, Albert Jan, Gorry Paul R, Jansson Marianne

Abstract excerpt

BACKGROUND: At early stages of infection CCR5 is the predominant HIV-1 coreceptor, but in approximately 50% of those infected CXCR4-using viruses emerge with disease progression. This coreceptor switch is correlated with an accelerated progression. However, those that maintain virus exclusively restricted to CCR5 (R5) also develop AIDS. We have previously reported that R5 variants in these "non-switch virus"...

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Share to Acquired Immunodeficiency Syndrome
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylation

Share to HIV Envelope Protein gp120

Share to Lectins, C-Type

Share to Receptors, CCR5

Share to Receptors, HIV

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Source

Open in PubMed Open full text

Identifiers

PMID: 18371209
DOI: 10.1186/1742-4690-5-28
PMCID: PMC2330154

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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