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Article

Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection.

Journal of virology - 1 Nov 1998

Kitchen S G, Korin Y D, Roth M D, Landay A, Zack J A

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD4. Costimulation of CD8(+)/CD4(-) T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells induced expression of CD4 and rendered these CD8 cells susceptible to HIV-1 infection. Naive CD45RA+ cells responded with greater expression of CD4 than did CD45RO+ cells. CD8(+) lymphocytes derived from...

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Identifiers

PMID: 9765450
DOI: 10.1128/JVI.72.11.9054-9060.1998
PMCID: PMC110322

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