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Article

Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters.

Virology journal - 3 Jun 2008

Schickli Jeanne H, Kaur Jasmine, Macphail Mia, Guzzetta Jeanne M, Spaete Richard R, Tang Roderick S

Abstract excerpt

BACKGROUND: Human metapneumovirus (hMPV) infection can cause acute lower respiratory tract illness in infants, the immunocompromised, and the elderly. Currently there are no licensed preventative measures for hMPV infections. Using a variant of hMPV/NL/1/00 that does not require trypsin supplementation for growth in tissue culture, we deleted the M2-2 gene and evaluated the replication of rhMPV/DeltaM2-2 virus in...

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Identifiers

PMID: 18519001
DOI: 10.1186/1743-422X-5-69
PMCID: PMC2426676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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