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Human Metapneumovirus M2-2 Protein Inhibits Innate Cellular Signaling by Targeting MAVS

27 Sept 2012

Abstract excerpt

Human metapneumovirus (hMPV) is a leading cause of respiratory infections in pediatric populations globally, with no prophylactic or therapeutic measures. Recently, a recombinant hMPV lacking the M2-2 protein (rhMPV-ΔM2-2) demonstrated reduced replication in the respiratory tract of animal models, making it a promising live vaccine candidate. However, the exact nature of the interaction between the M2-2 protein...

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PMID: 23015697
DOI: 10.1128/jvi.01248-12

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