Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The M2-2 protein of human respiratory syncytial virus is a regulatory factor involved in the balance between RNA replication and transcription.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 1999

Bermingham A, Collins P L

Abstract excerpt

The M2 mRNA of human respiratory syncytial virus (RSV) contains two overlapping ORFs, encoding the transcription antitermination protein (M2-1) and the 90-aa M2-2 protein of unknown function. Viable recombinant RSV was recovered in which expression of M2-2 was ablated, identifying it as an accessory factor dispensable for growth in vitro. Virus lacking M2-2 grew less efficiently than did the wild-type parent in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Viral
Share to Blotting, Northern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HN Protein

Share to Open Reading Frames

Share to Respiratory Syncytial Virus, Human

Share to RNA, Viral

Share to Viral Envelope Proteins

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 10500164
DOI: 10.1073/pnas.96.20.11259
PMCID: PMC18021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The M2-2 protein of human respiratory syncytial virus is a regulatory factor involved in the balance between RNA replication and transcription.PMID 10500164Read ↗

Respiratory Syncytial Virus That Lacks Open Reading Frame 2 of the M2 Gene (M2-2) Has Altered Growth Characteristics and Is Attenuated in RodentsSemantic proximity Read ↗

Altered Growth Characteristics of Recombinant Respiratory Syncytial Viruses Which Do Not Produce NS2 ProteinSemantic proximity Read ↗

Deletion of M2 Gene Open Reading Frames 1 and 2 of Human Metapneumovirus: Effects on RNA Synthesis, Attenuation, and ImmunogenicitySemantic proximity Read ↗

Role of the M2-1 Transcription Antitermination Protein of Respiratory Syncytial Virus in Sequential TranscriptionSemantic proximity Read ↗

Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5' proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development.Semantic proximity Read ↗

Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate With Deletion of RNA Synthesis Regulatory Protein M2-2 is Highly Immunogenic in ChildrenSemantic proximity Read ↗

The role of M2 proteins of pneumoviruses in transcription regulation, prevention of hypermutation, and activation of the type I interferon pathway.Semantic proximity Read ↗

Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouseSemantic proximity Read ↗

Respiratory syncytial virus M2-1 protein associates non-specifically with viral messenger RNA and with specific cellular messenger RNA transcriptsSemantic proximity Read ↗

The NS1 protein of human respiratory syncytial virus is a potent inhibitor of minigenome transcription and RNA replication.Semantic proximity Read ↗

Requirement of cysteines and length of the human respiratory syncytial virus M2-1 protein for protein function and virus viability.Semantic proximity Read ↗

Human Metapneumovirus M2-2 Protein Inhibits Innate Cellular Signaling by Targeting MAVSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.