Article
Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system.
PLoS genetics - 30 May 2008
Berger Jürg, Senti Kirsten-André, Senti Gabriele, Newsome Timothy P, Asling Bengt, Dickson Barry J, Suzuki Takashi
Abstract excerpt
Forward genetic screens in model organisms are an attractive means to identify those genes involved in any complex biological process, including neural circuit assembly. Although mutagenesis screens are readily performed to saturation, gene identification rarely is, being limited by the considerable effort generally required for positional cloning. Here, we apply a systematic positional cloning strategy to...
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