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Article

Increased organophosphate scavenging in a butyrylcholinesterase mutant.

Chemico-biological interactions - 25 Sept 2008

Geyer Brian C, Woods Ryan R, Mor Tsafrir S

Abstract excerpt

Nicotiana benthamiana plant lines expressing a reengineered human butyrylcholinesterase (BChE) with enhanced cocaine hydrolase activity were created. Subsequent purification and biochemical analysis revealed that compared to wild-type butyrylcholinesterase, the cocaine hydrolase displayed increased affinity to the organophosphate (OP) pesticides paraoxon (6.8 4x 10(-10)M vs. 1.11 x 10(-8)M) and malaoxon (9.81 x...

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Identifiers

PMID: 18514178
DOI: 10.1016/j.cbi.2008.04.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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