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Article

Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine.

Chemico-biological interactions - 6 Sept 2010

Yang Wenchao, Xue Liu, Fang Lei, Chen Xi, Zhan Chang-Guo

Abstract excerpt

Cocaine addiction and overdose are a well-known public health problem. There is no approved medication available for cocaine abuse treatment. Our recently designed and discovered high-activity mutant (A199S/S287G/A328W/Y332G) of human butyrylcholinesterase (BChE) has been recognized to be worth exploring for clinical application in humans as a potential anti-cocaine medication. The catalytic rate constant...

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Identifiers

PMID: 20060817
DOI: 10.1016/j.cbi.2010.01.004
PMCID: PMC2891156

Genes

BTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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