Identification of functional human splenic memory B cells by expression of CD148 and CD27.

doi:10.1084/jem.188.9.1691

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Identification of functional human splenic memory B cells by expression of CD148 and CD27.

The Journal of experimental medicine - 2 Nov 1998

Tangye S G, Liu Y J, Aversa G, Phillips J H, de Vries J E

Abstract excerpt

Memory B cells isolated from human tonsils are characterized by an activated cell surface phenotype, localization to mucosal epithelium, expression of somatically mutated immunoglobulin (Ig) variable (V) region genes, and a preferential differentiation into plasma cells in vitro. In spleens of bo...

Topics

B-Lymphocyte Subsets
B-Lymphocytes
Base Sequence
Biomarkers
Cell Differentiation
DNA Primers
Genes, Immunoglobulin
Humans
Immunoglobulin Variable Region
Immunologic Memory
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymerase Chain Reaction

Protein Tyrosine Phosphatases

Receptor-Like Protein Tyrosine Phosphatases, Class 3

Sequence Homology, Nucleic Acid

Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 9802981
DOI: 10.1084/jem.188.9.1691
PMCID: PMC2212517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9802981-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of functional human splenic memory B cells by expression of CD148 and CD27.PMID 9802981Read ↗

Surface phenotypes of naive and memory B cells in mouse and human tissues.Semantic proximity Read ↗

The Splenic Marginal Zone in Children Is Characterized by a Subpopulation of CD27-Negative, Lowly IGHV-Mutated B Cells.Semantic proximity Read ↗

Systematic memory B cell archiving and random display shape the human splenic marginal zone throughout life.Semantic proximity Read ↗

CD27: a memory B-cell marker.Semantic proximity Read ↗

Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95.Semantic proximity Read ↗

Human B cells express a CD45 isoform that is similar to murine B220 and is downregulated with acquisition of the memory B‐cell marker CD27Semantic proximity Read ↗

Memory B cells: effectors of long-lived immune responses.Semantic proximity Read ↗

Phenotypic, transcriptomic, and spatial characterization of CD45RB+ naïve mature B cells: Implications in Sjögren's disease.Semantic proximity Read ↗

Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients.Semantic proximity Read ↗

Human CD43+ B cells are closely related not only to memory B cells phenotypically but also to plasmablasts developmentally in healthy individuals.Semantic proximity Read ↗

[Heterogeneity and function of human B lymphocytes].Semantic proximity Read ↗

A New Memory CD27−IgG+ B Cell Population in Peripheral Blood Expressing VH Genes with Low Frequency of Somatic MutationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.