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Article

Probenecid, but not cystic fibrosis, alters the total and renal clearance of fexofenadine.

Journal of clinical pharmacology - 1 Aug 2008

Liu Shanshan, Beringer Paul M, Hidayat Levita, Rao Adupa P, Louie Stan, Burckart Gilbert J, Shapiro Bertrand

Abstract excerpt

This study aims to evaluate renal P-glycoprotein (P-gp) activity in patients with cystic fibrosis. P-gp efflux activity in peripheral T cells was measured by flow cytometry in 10 cystic fibrosis and 15 healthy volunteers. Eight cystic fibrosis patients and 8 healthy volunteers were recruited into a crossover pharmacokinetic study in which participants received 180 mg fexofenadine with or without 1 g probenecid...

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Identifiers

PMID: 18511651
DOI: 10.1177/0091270008319707

Genes

ABCB1

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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