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Article

The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.

Clinical pharmacology and therapeutics - 1 Jan 2010

Picard N, Yee S W, Woillard J-B, Lebranchu Y, Le Meur Y, Giacomini K M, Marquet P

Abstract excerpt

The goal of this study was to determine the roles of the organic anion-transporting polypeptides (OATPs) OATP1A2, OATP1B1, and OATP1B3 and their genetic variants in the pharmacokinetics of the immunosuppressive drug mycophenolate mofetil (MMF). Using OATP-transfected human embryonic kidney (HEK) cells, we measured the uptake of mycophenolic acid (MPA) and its glucuronide (MPAG). MPAG, but not MPA, significantly...

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Identifiers

PMID: 19890249
DOI: 10.1038/clpt.2009.205
PMCID: PMC2884029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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