Article
Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission.
The Journal of infectious diseases - 1 Jul 2008
Zhang Jing, Zhang Xinsheng, Fu Jihua, Bi Zhenqiang, Arheart Kristopher L, Barreiro Luis B, Quintana-Murci Lluis, Pahwa Savita, Liu Huanliang
Abstract excerpt
To investigate the role that DC-SIGN neck-region length variation plays in HIV-1 transmission, we studied 530 HIV-1-positive and 341 HIV-1-negative individuals in China. The carrier frequency of a DC-SIGN allele with <5 repeat units in the neck-region was 0.9% in HIV-1-positive and 3.8% in HIV-1-negative individuals (P=.007), an observation suggesting that this DC-SIGN variation plays a role in HIV-1...
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