Article
HIV-1 infected Germans have more variations on neck region of DC-specific intercellular adhesion molecule-3-grabbing nonintegrin than HIV-1 infected Chinese.
European journal of medical research - 25 Feb 2008
Li-Jun X, Brockmeyer N H, Bader A, Hang-Ping Y, Zhi-Gang W, Nanping Wu
Abstract excerpt
The C-type lectins DC-SIGN and DC-SIGNR bind and transmit HIV-1 depending on the tetramer formed by "neck" region and carbohydrate recognition domain (CRD). Recent studies indicated polymorphisms in neck region of DC-SIGNR were more frequent and associated with susceptibility to HIV-1 infection, whereas no similar trends were observed on DC-SIGN for rare variations of DC-SIGN among the researched subjects in...
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