Article
Elevation of cystatin C in susceptible neurons in Alzheimer's disease.
The American journal of pathology - 1 Sept 2001
Deng A, Irizarry M C, Nitsch R M, Growdon J H, Rebeck G W
Abstract excerpt
A common polymorphism in the cystatin C gene is associated with increased risk of developing Alzheimer's disease (AD). To explore possible neuropathological consequences of this genetic association, we examined expression of cystatin C in brains from 22 AD and 11 control patients by immunohistochemistry. In the temporal cortex of all AD brains, there was strong cystatin C immunostaining of neurons and activated...
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