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Article

Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation.

Neurobiology of aging - 1 Sept 2004

Sastre Magdalena, Calero Miguel, Pawlik Monika, Mathews Paul M, Kumar Asok, Danilov Vlatko, Schmidt Stephen D, Nixon Ralph A, Frangione Blas, Levy Efrat

Abstract excerpt

The colocalization of cystatin C, an inhibitor of cysteine proteases, with amyloid beta (Abeta) in parenchymal and vascular amyloid deposits in brains of Alzheimer's disease (AD) patients may reflect cystatin C involvement in amyloidogenesis. We therefore sought to determine the association of cystatin C with Abeta. Immunofluorescence analysis of transfected cultured cells demonstrated colocalization of cystatin...

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Identifiers

PMID: 15212828
DOI: 10.1016/j.neurobiolaging.2003.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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