Article
The late retinoic acid induction of laminin B1 gene transcription involves RAR binding to the responsive element.
The EMBO journal - 1 May 1991
Vasios G, Mader S, Gold J D, Leid M, Lutz Y, Gaub M P, Chambon P, Gudas L
Abstract excerpt
Transcription of the murine laminin B1 (LB1) gene is induced by retinoic acid (RA), but responds only 24-28 h after RA treatment in F9 EC cells. Here we have shown by gel retardation assay that all three retinoic acid receptors (RARs) alpha, beta and gamma expressed in Cos cells can bind directly to the previously characterized retinoic acid response element (RARE) of the LB1 promoter, albeit with a weaker...
Topics
- Base Sequence
- Binding Sites
- Biological Evolution
- Carrier Proteins
- DNA, Superhelical
- Gene Expression Regulation
- Genetic Vectors
- HeLa Cells
- Humans
- Laminin
- Molecular Sequence Data